QUALITY STANDARDS – STILL UNUSED POTENCIAL

Kvaliteta je danas vjerojatno riječ koja se najviše spominje u poslovnom svijetu, bez obzira o kojoj se ljudskoj djelatnosti radi. Upravljanje kvalitetom, sustavi kvalitete, totalna kvaliteta, alati za mjerenje kvalitete, standardi ili norme kvalitete i mnogi drugi pristupi i metode pomažu u nastojanju tvrtke da posluje uspješno u svim aspektima i segmentima. U radu će se dati pregled razloga nepotpune iskorištenosti potencijala poboljšanja u tvrtki koje uvođenje sustava kvalitete prema seriji normi ISO 9000 omogućava, te će se ukazati na uobičajene pogreške i propuste pri uvođenju sustava kvalitete ISO 9001. Pojasnit će se evolucija normi od prve do zadnje revizije i usporediti potencijalne koristi na poslovanje svake od verzija. Rad će dati pregled istraživanja koja dokazuju vezu između uspostave ISO 9001 sustava upravljanja kvalitetom i poboljšanim različitim aspektima u poslovanju. Navest će se niz smjernica i savjeta kako se pripremiti te uspješno provoditi uvođenje u tvrtku sustava kvalitete po ISO 9001, te kako uspješno nastaviti poslovanje nakon dobivanja certifikata. U radu su prezentirani i rezultati mjerenja stavova, prikupljeni na uzorku od 52 ispitanika s ciljem da se ispita razina informiranosti o učincima uvođenja normi u poslovanje, te da se ispita koliku važnost nosi korisniku posjedovanje certifikata tvrtke čije usluge i/ili proizvode koristi.Today, quality is a word that is probably most frequently mentioned in the business world, regardless of the human activity in question. Quality management, quality systems, total quality tools for measuring quality, quality standards and many other approaches and methods help a company to operate successfully in all its aspects and segments. This paper will review the reasons for incomplete utilization of potential for improvements in the company where a quality system according to the ISO 9000 series has been introduced, and common mistakes and failures in the implementation of the ISO 9001 quality system will be pointed out. The evolution of standards from the first to the last revision will be calrified and the potential benefits to the business of each version will be compared. The paper will give an overview of studies that prove a connection between the establishment of the ISO 9001 quality management system and the improvement of various aspects of the business. A number of guidelines and tips on how to prepare and successfully implement a quality system in accordance with the ISO 9001 will be mentioned as well as how to continue operations successfully after obtaining a certification. The paper presents the results of measurements of attitudes obtained on a sample of 52 subjects. The purpose has been to examine the level of their knowledge about the effects of the ISO 9001 standard introduction in business, and to investigate how important is to a user to hold a certification of the company whose services and / or products s/he uses

Prilog razmatranju dobrobiti živine sa aspekta uticaja i kontrole crvene kokošije grinje (Dermanyssus gallinae)

Technological solutions and environmental conditions have a significant impact on infestation intensity and the problems around D. gallinae control. Changes in keeping laying hens in EU, in terms of D. gallinae influence, have not led to the welfare of the layers. On the contrary, they have contributed to the spreading of disease, have worsened conditions for control and accentuated harmful consequences. Apart from the poultry, these changes have also had a negative impact on the welfare of humans, through a toxicological and zootonic risk, and economic damages. Conventional cages so far provide the most appropriate environment for D. gallinae control. Opportunities for improving, even solving the problem of D. gallinae control in egg production do exist, however they require a changing the entire approach hitherto.Tehnološka rešenja i ambijentalne prilike bitno utiču na intezitet infestacije i problematičnost kontrole D. gallinae. Promene u načinu držanja kokošaka nosilja u EU, sa aspekta uticaja D. gallinae, nisu dovele do dobrobiti nosilja. Naprotiv, doprinele su širenju bolesti, pogoršale uslove kontrole i naglasile štetne posledice. Osim na živinu, promene su nepovoljno uticale na dobrobit čoveka kroz toksikološki i zoonotski rizik, i ekonomske štete. Konvencionalni kavezi obezbeđuju do sad najprikladniji ambijent za kontrolu D. gallinae. Mogućnosti za unapređenje, pa i rešenje kontrole D. gallinae u proizvodnji jaja postoje, ali ona zahteva promenu celokupnog dosadašnjeg pristupa

Razgradivost proteina zelene mase sa travnjaka u uslovima prolećne pregonske ispaše

A cutting experiment was conducted to analyze the changes in the crude protein (CP) fraction content and in the estimated ruminal protein degradability of forage, obtained in conditions of simulated rotational spring grazing on permanent grassland. The field trial was conducted on permanent pasture during 2015 and included three cuttings as a simulated rotational spring grazing. For determination of protein degradability of pasture forage, the fractionation of the CP according to Cornell Net Carbohydrate and Protein System (CNCPS v6.5) and the Streptomyces griseus protease assay were used. Relative to CP, no significant differences were found among cuts for ammonia N content (A1 fraction) and for protein fraction C which is completely unavailable to the animals. Values for soluble true protein (A2 fraction) and cell wall-associated protein, which is acid detergent soluble (B2), were significantly increased (p lt 0.05) while a significant reduction (p lt 0.05) of the moderately degradable protein (B1) content was determined during the growing season. The lower rumen degradable protein (RDP) content of grassland herbage was obtained in the second cut which was significant (p lt 0.05) according to the CNCPS procedure. Obtained high solubility and degradability of CP in pasture require adequate content of readily available carbohydrates in rations for grazing ruminants to provide efficient utilization of consumed protein.Istraživanje je obavljeno u cilju utvrđivanja promena u sadržaju frakcija sirovog proteina (SP) i ruminalne razgradivosti proteina zelene mase dobijene košenjem prirodnog travnjaka u uslovima koji su odgovarali rotacijskoj pregonskoj ispaši tokom prolećne sezone. Poljski ogled je izveden na permanentnom pašnjaku tokom proleća 2015. godine i uključivao je tri otkosa koji su odgovarali ciklusima ispaše. Za determinisanje razgradivosti proteina zelene mase, frakcionisanje sirovog proteina je obavljeno prema proceduri Cornell Net Carbohydrate and Protein System (CNCPS v6.5), kao i primenom in vitro metode korišćenjem Streptomyces griseus proteaze. U odnosu na SP, nisu utvrđene značajne razlike između otkosa - ciklusa ispaše u pogledu sadržaja amonijačnog N (frakcija A1), kao i u pogledu sadržaja proteinske frakcije C, koja je potpuno nedostupna životinjama. Sadržaj rastvorljivog pravog proteina (frakcija A2) i proteina vezanog za ćelijski zid, koji je rastvorljiv u kiselom deterdžentu (frakcija B2) se značajno povećavao (p lt 0,05), dok se sadržaj umereno razgradive frakcije proteina (B1) značajno smanjivao (p lt 0,05) tokom prolećne sezone vegetacije. Najmanja vrednost za ruminalnu razgradivost i učešće RDP (protein razgradiv u rumenu) u SP zelene mase sa pašnjaka utvrđena je u drugom otkosu, a ova razlika je bila značajna (p lt 0,05) kada je ruminalna razgradivost proteina determinisana korišćenjem procedure CNCPS. Utvrđeno visoko učešće rastvorljive frakcije SP i visoka ruminalna razgradivost SP zelene mase sa pašnjaka ukazuju na potrebu podrobnijeg balansiranja obroka za preživare na paši u pogledu sadržaja lako razgradivih ugljenih hidrata, a u cilju obezbeđenja efikasnog iskorišćavanja konzumiranog proteina

AN APPROACH FOR COMMUNICATION RELAIBILITY USING SELF-ADAPTIVE AUTONOMIC COMPUTING TECHNIQUES

Interdependency of electric power grids and information and communication technology is a rapidly growing topic. With the introduction of Smart Grid, handling dynamic load tracking, dynamic tariffs, clients that can consume but also produce electricity that can be delivered to the grid has become a part of everyday operational cycles within power supply companies. Hence, electricity distribution and power supply companies are in need for introduction of efficient mechanisms for the optimal tracking and use of available electric energy. In this paper, we describe the low voltage (LV) distribution network monitoring system developed for the Electric Power Industry of Serbia (EPS) electricity distribution company. The system we present is implemented in a way so that it provides abilities to measures, communicates and stores real-time data, translating it into actionable information needed by EPS to meet the described challenges regarding LV distribution networks. The implemented system is using self-adaptive autonomic computing techniques to provide a reliable data transfer from measurement devices deployed in different parts of the LV distribution network

Prediction of GO terms for IDPs based on highly connected components in PPI networks

Partitioning large biological networks can help biologists to retrieve new information for particular biological structures. In literature, various methods for partitioning and clustering biological networks have been proposed. The aim of such a network partitioning is to retrieve smaller structures which are easier to analyse, but still containing important information about relations between the network elements. Highly connected deletion problem is one of such network partitioning, with the aim to partition a network into highly connected components (hcd components) by deleting minimum number of edges. A network component with n nodes is a hcd component if the degree of every vertex is larger than n/2. For the purpose of this research, we used a specially constructed local search based heuristic approach to identify hcd components. Dealing with protein-protein interaction (PPI) networks, it has been noticed that proteins from the same hcd component in a network have same Gene Ontology (GO) annotations. Based on that, we proposed a new method for prediction of GO annotations, which consists of the following steps: (a) starting PPI network is partitioned to hcd components; (b) the obtained hcd components are expanded by proteins which became singletons in the partition set; (c) the newly formed extended hcd components are the subject of further enrichment analysis in DiNGO tool, which returns a list of existing GO terms for proteins from the considered extended component; (d) after propagation through GO hierarchy, the extended list of GO is obtained; (e) each protein from the extended hcd component is annotated by a number of GO terms obtained from the previous step; The proposed method is tested on the data from CAFA-3 challenge. Comparing the F1-measure of the obtained results, a combination of parameters (type of extension, cutoff for enrichment analysis and maximum number of GO terms) with the best performances is selected for the further usage. The method with the selected parameters was further applied on a class of Intrinsically Disordered Proteins (IDP). Preliminary results indicate that this method can be useful for proposing new GO terms for IDP proteins

The effect of tannin supplementation of mid-lactation dairy cows diets on metabolic profile parameters and production characteristics

The aim of this study was to examine the effect of using tannin supplement in ration for mid-lactation dairy cows (90 +/- 17 days in milk) and the number of lactation on metabolic profile parameters values. Additionally, the effect of tannin supplementation on cows' production characteristics in the 2nd lactation was evaluated. Research was conducted on 80 Holstein cows divided into two groups of 40 cows (control and experimental group) that included 16 cows in 2nd and 12 in 3rd and 4th lactation. The tannin supplement Tanimil SCC (40 g/cow/day; 40% of tannins) was added in the total mixed ration (TMR) of experimental group, while the control group of cows was fed ration without the tannin supplement. The trial lasted 60 days. Dairy cows, fed diet supplemented with tannin, had markedly lower values (P lt 0.05) of B-hydroxybutyrate concentration (0.79 vs. 0.96 mmol/L) and lower blood urea concentration (5.89 vs. 6.93 mmol/L). Difference in the blood glucose concentrations (3.92 vs. 3.89 mmol/L) was not significant. The lactation number had no significant effect on values of metabolic profile parameters (concentration of glucose, B-hydroxybutyrate and urea). The effect of interaction of lactation number and tannin supplement on the values of examined parameters of metabolic profile was not significant. Supplementation of tannin in the diet for cows in the second lactation, had a positive effect (P lt 0.05) on the milk yield (4.42%) and yield of 4% fat corrected milk (FCM, 5.24%). The use of tannin, improved concentration (3.20 vs. 3.12%) and yield (from 1.16 to 1.24 kg/day) of milk protein (P lt 0.05). Addition of tannin also improved concentration and yield of milk fat, as well as the concentration of lactose. The supplementation of Tanimil SCC to mid-lactation dairy cows had a positive impacts on reduction of blood content of B-hydroxybutyrate and urea, and improved productive performances of cows in the second lactation

Uticaj selena i vitamina E na zdravlje mlečne žlezde krava

In this paper the literature data on the effect of Se and vitamin E on health condition of mammary gland in cows have been discussed. The frequency and occurrence of mastitis are in correlation with the status of vitamin E and Se, and they are connected with rate of clinical mastitis and somatic cells count in collected heard milk. Supplementation of these micronutritients in Se-deficient cow rations results in improving of immunological response. In rations for high-productive cows in intensive production more than often the share of these nutrients is less than necessary what can partly explain the frequent occurrence of mastitis in our country.U radu su sagledani literaturni podaci o uticaju Se i vitamina E na zdravstveno stanje mlečne žlezde krava. Učestalost pojave i izraženost mastitisa u korelaciji su sa statusom vitamina E i Se, a u vezi su i sa stopom kliničkog mastitisa i brojem somatskih ćelija u zbirnom mleku stada. Dodavanje ovih mikronutritienata u hranu kod postojanja deficita rezultira poboljšanjem imunološkog odgovora. U obrocima za visokoproduktivne krave u intenzivnoj proizvodnji često je njihova zastupljenost manja od potrebne, što delom može objasniti povećanu učestalost pojave mastitisa u našoj zemlji

LncRNAs as Regulators of Atherosclerotic Plaque Stability

Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced and unstable atherosclerotic plaques most often trigger acute coronary events that can lead to fatal outcomes. However, despite the fact that different plaque phenotypes may require different treatments, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes. Long non-coding RNAs (lncRNAs) represent an important class of molecules that are implicated in epigenetic control of numerous cellular processes. Here we review the latest knowledge about lncRNAs’ influence on plaque development and stability through regulation of immune response, lipid metabolism, extracellular matrix remodelling, endothelial cell function, and vascular smooth muscle function, with special emphasis on pro-atherogenic and anti-atherogenic lncRNA functions. In addition, we present current challenges in the research of lncRNAs’ role in atherosclerosis and translation of the findings from animal models to humans. Finally, we present the directions for future lncRNA-oriented research, which may ultimately result in patient-oriented therapeutic strategies for ASCVD

Rasejanje svetlosti i tehnike u biološkim i biomedicinskim problemima

Biološke i biomedicinske sredine sadrže veliki broj čestica različitog oblika i veličine koje predstavljaju potencijalne centre rasejanja laserske svetlosti u analizi dinamike i strukture biološke materije. U zavisnosti od oblika, veličina i medjusobne interakcije rasejavača, sredina se modeluje na različite načine. Proučavanjem problema rasejanja svetlosti u biološkim sredinama pojavljuje se potreba za razmatranjem dva krajnja slučaja u kojima se analiziraju centri rasejanja kao nezavisni, i slučajevi kod kojih postoji interakcija. U tom slučaju korelacione funkcije se eksplctitno ne mogu izbeći. Među– slučajevi (između pomenuta dva krajnja) se razmatraju u raznim stepenima interakcija među centrima; problem modelovanja postaje znatno složeniji. U radu je redstavljen jedan način modelovanja ansambla rasejavača biološke sredine čiji se oblik može smatrati cilindričnim. Ovakav model je primenljiv na veliki broj bioloških sistema u kojima su rasejavači svetlosti razni mikroorganizmi, (bakterije, virusi, gljivice i dr), ili pak, neki drugi elementi živih tkiva.Biomedic and biologic media consist on a large number of particles with different dimensions and shapes representing potential laser light scattering centers in analyse of dynamics and structure of biologic substance. Dependence on shape, dimensions and mutual interactions of scatterers medium is modelled in various ways. The studing some problems of light scattering light in biological media has to be considered as two boundary major cases: the analyses of independent centres of scattering, and the case where the centres are mutualy dependent objects. In such case correlation functions are explicite non avoidable. The cases between the major two, are considered on different levels of interaction between centres; modelling roblem becomes more complex. Modelling of the scatterrers ansamble in biological media where the the cyilindrical geometry is in case is anaysed in this paper. This model could be applied to many biological systems where the scatterrers are different microorganisms (bacteria, viruses, micose etc.), or some other parts of the living tissue

Rasejanje svetlosti i tehnike u biološkim i biomedicinskim problemima

Biološke i biomedicinske sredine sadrže veliki broj čestica različitog oblika i veličine koje predstavljaju potencijalne centre rasejanja laserske svetlosti u analizi dinamike i strukture biološke materije. U zavisnosti od oblika, veličina i medjusobne interakcije rasejavača, sredina se modeluje na različite načine. Proučavanjem problema rasejanja svetlosti u biološkim sredinama pojavljuje se potreba za razmatranjem dva krajnja slučaja u kojima se analiziraju centri rasejanja kao nezavisni, i slučajevi kod kojih postoji interakcija. U tom slučaju korelacione funkcije se eksplctitno ne mogu izbeći. Među– slučajevi (između pomenuta dva krajnja) se razmatraju u raznim stepenima interakcija među centrima; problem modelovanja postaje znatno složeniji. U radu je redstavljen jedan način modelovanja ansambla rasejavača biološke sredine čiji se oblik može smatrati cilindričnim. Ovakav model je primenljiv na veliki broj bioloških sistema u kojima su rasejavači svetlosti razni mikroorganizmi, (bakterije, virusi, gljivice i dr), ili pak, neki drugi elementi živih tkiva.Biomedic and biologic media consist on a large number of particles with different dimensions and shapes representing potential laser light scattering centers in analyse of dynamics and structure of biologic substance. Dependence on shape, dimensions and mutual interactions of scatterers medium is modelled in various ways. The studing some problems of light scattering light in biological media has to be considered as two boundary major cases: the analyses of independent centres of scattering, and the case where the centres are mutualy dependent objects. In such case correlation functions are explicite non avoidable. The cases between the major two, are considered on different levels of interaction between centres; modelling roblem becomes more complex. Modelling of the scatterrers ansamble in biological media where the the cyilindrical geometry is in case is anaysed in this paper. This model could be applied to many biological systems where the scatterrers are different microorganisms (bacteria, viruses, micose etc.), or some other parts of the living tissue